Guardiola's side visit the London Stadium on Sunday with Hammers still fighting for survival
Manchester City visit West Ham United on Sunday with their hosts' Premier League status still hanging in the balance.
A 4-1 defeat at Arsenal last weekend left the Hammers six points off the bottom three with four games remaining.
With Leicester City, Manchester United and Everton still to play, West Ham's safety is far from guaranteed.
League champions City showed no signs of taking their foot off the gas with a comprehensive 5-0 victory over Swansea City on Sunday and they seem intent on smashing through the 100 points barrier for the season.
West Ham boss David Moyes could welcome back James Collins from a thigh injury, but Pedro Obiang, Michail Antonio, Winston Reid and Sam Byram remain on the sidelines.
Benjamin Mendy made his first appearance for City since last September against Swansea and he could be handed a start at the London Stadium.
Fernandinho is available again after serving a two-game ban for picking up 10 yellow cards, but John Stones and Sergio Aguero are both ruled out.
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West Ham's recent record against City is poor, with the London club winning just two of their last 18 meetings in all competitions.
The Hammers have recorded just two victories in their last 12 matches and their record of 63 goals conceded this season is the second worst in the Premier League.
The last four meetings between these two sides have resulted in a 14-2 aggregate scoreline of City and it's difficult to imagine Pep Guardiola's side having too many problems this weekend.
City recovered from a goal down to win 2-1 when the teams met at the Etihad Stadium back in December.
Angelo Ogbonna's header on the stroke of half-time put the Hammers ahead, but second-half goals by Nicolas Otamendi and David Silva won it for City.
With the pressure now off City after being confirmed as champions, they can be expected to showcase their undoubted talent in their remaining games.
Their victory over Swansea took their goals tally to 98 for the season and just two defeats in the league this term is a measure of the manner they have dominated for the majority of the campaign.
City look banker material to beat West Ham this weekend and leave Moyes sweating ahead of the final few games.